Nonalcoholic fatty liver disease (NAFLD) is a major public health problem that will only worsen in the future, as it is closely linked to the epidemics of obesity and type 2 diabetes mellitus. Given this link, endocrinologists and primary care physicians are in an ideal position to identify persons at risk to prevent the development of cirrhosis and comorbidities. Join endocrine expert Vin Tangpricha, M.D., Ph.D., as he interviews AACE Co-Chairs, guideline task force experts, Kenneth Cusi, MD, FACP, FACE, and Scott D. Isaacs, MD, FACP, FACE, about the newly released 2022 clinical practice guideline for the diagnosis and management of nonalcoholic fatty liver disease, published in the May 2022 issue of Endocrine Practice (https://www.endocrinepractice.org/article/S1530-891X(22)00090-8/fulltext).