2022 Clinical Practice Guideline for Development of a Diabetes Mellitus Comprehensive Care Plan

This updated guideline provides recommendations for the care and management of people with or at risk for diabetes mellitus at every stage, including prevention, diagnosis, and treatment.

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The authors of the guideline identified a few errata. Download the corrigendum to learn about changes that reflect up-to-date best practice.

Download Corrigendum


The guideline addresses a variety of new topics related to management of diabetes, including COVID-19 vaccination, telehealth, social determinants of health, male and female infertility, secondary diabetes, and nutritional supplements. This update also includes expanded sections on management of hyperglycemia in the hospital setting and hypoglycemia, quality of life recommendations on sleep hygiene and depression, and updated safety-oriented recommendations on occupational risk and risk of cancer.

The 2022 guideline update synthesizes thousands of articles to provide health care professionals with the latest evidence-based information on the total care of diabetes. Particularly important updates of this guideline include: 

  • Complications-centric recommendations for the use of pharmacotherapy for the management of persons with diabetes
  • Recommendations, based on the latest landmark cardiovascular outcome trials, on the use of newer antihyperglycemic therapies with enhanced safety and classes of drugs that reduce the risk of cardiovascular disease, heart failure, and/or chronic kidney disease, independent of glycemic control
  • To improve glycemia and address the risk or presence of cardiometabolic complications, recommendations for FDA-approved weight-loss medications and comprehensive guidance on the management of obesity, which is a cornerstone of care of persons with diabetes
  • Recommendations for management of comorbidities and complications, including obesity, hypertension, dyslipidemia, retinopathy, neuropathy, diabetic/chronic kidney disease, and cardiovascular disease

The writing team of nearly 30 experts was led by co-chairs Drs. Lawrence Blonde and Guillermo Umpierrez and section leaders Drs. Sethu Reddy and Janet McGill.

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Listen to podcast episode 35 to learn about the 2022 AACE diabetes clinical practice guideline featuring 170 updated and new evidence-based recommendations for the care and management of people with or at risk for diabetes mellitus.