Common Comorbidities and Complications of Prediabetes

Obesity is a neuroendocrine disease that is itself associated with numerous metabolic and biomechanical complications. It is generally defined as a body mass index (BMI) ≥30 kg/m2, especially in the presence of obesity-related complications. In the context of prediabetes, obesity (1-3):

  • Increases risk of progression to type 2 diabetes (T2D), especially among patients with abdominal obesity
  • Increases risk of cardiovascular comorbidities (hypertension, dyslipidemia, atherosclerosis)
  • May limit patient’s ability to engage in physical activity due to joint disorders and other mobility constraints
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